Long - term changes in energy expenditure and body composition after massive weight loss induced by gastric bypass surgery 1 - 4

Background: Little is known about the determinants of individual variability in body weight and fat loss after gastric bypass surgery or about the effects of massive weight loss induced by this surgery on energy requirements. Objectives: The objectives were to determine changes in energy expenditure and body composition with weight loss induced by gastric bypass surgery and to identify presurgery predictors of weight loss. Design: Thirty extremely obese women and men with a mean (±SD) age of 39.0 ± 9.6 y and a body mass index (BMI; in kg/m2) of 50.1 ± 9.3 were tested longitudinally under weight-stable conditions before surgery and after weight loss and stabilization (14 ± 2 mo). ,Tdt'll en~rgy expenditure (TEE), resting energy expenditure (REE), body composition, and fasting leptin were measured. Results: Subjects lost 53.2 ± 22.2 kg body weight and had significant decreases in REE (-2.4 ± 1.0 MJ/d ; P < 0.001) and TEE (3.6 ± 2.5 MJ/d; P < 0.001). Changes in REE were predicted by changes in fat-free mass and fat mass. The average physical activity level (TEE/REE) was 1.61 at both baseline and followup (P = 0.98). Weight loss was predicted by baseline fat mass and BMI but not by any energy expenditure variable or leptin. Measured REE at follow-up was not significantly different from predicted REE. Conclusions: TEE and REE decreased by 25 % on average after massive weight loss induced by gastric bypass surgery. REE changes were predicted by loss of body tissue; thus, there was no significant long-term change in energy efficiency that would independently promote weight regain . Am J Clin Nutr 2003;78:22-30.